According to senior U.S. officials, President Joe Biden will meet Chinese President Xi Jinping in person on Wednesday for the first time in a year. This is high-stakes diplomacy meant to defuse tensions between the two superpowers in the world.

Teams of officials from Beijing and Washington will be involved in the widely awaited exchange, which is expected to take hours, on the fringes of the Asia-Pacific Economic Cooperation (APEC) meeting taking place in the San Francisco Bay area.

It is expected to cover global issues from the Israel-Hamas war to Russia’s invasion of Ukraine, North Korea’s ties with Russia, Taiwan, the Indo-Pacific, human rights, fentanyl, artificial intelligence, as well as “fair” trade and economic relations, the officials said.

“Nothing will be held back; everything is on the table,” one senior Biden administration official who declined to be named told reporters.

U.S. officials, who have been pushing for the meeting for the better part of a year, believe Beijing has actively been working to undermine U.S. policy around the world.