UK authorities have arrested six men including a Briton off the coast of Plymouth and seized more than two tonnes (2,000kg) of cocaine.
The British man, from Stockton-on-Tees, and five Nicaraguans were arrested on a luxury yacht on Thursday.
The men, aged from 24 to 49, were held on suspicion of drug trafficking and remain in custody, the National Crime Agency (NCA) said.
Officers estimate the street value of the drugs is about $220 million.
The group were sailing in the Jamaican-flagged Kahu, and had travelled from the Caribbean, when they were intercepted 80 miles off the coast of Devon.
The arrests were made as part of an operation led by the NCA and supported by the Australian Federal Police (AFP) and Border Force.