SAWT BEIRUT INTERNATIONAL

| 19 April 2024, Friday |

Pfizer COVID-19 vaccine safe, effective on adolescents in trial, companies say

Pfizer Inc and BioNTech SE announced on Wednesday that their coronavirus vaccine was safe and effective and produced robust antibody responses in 12- to 15-year olds, paving the way for them to seek U.S. emergency use authorization in weeks.

Pfizer hopes that vaccinations of the group could kick off before the next school year, Albert Bourla, Pfizer’s chairman and chief executive, said in a statement.

Pfizer’s vaccine is already authorized for use in people starting at age 16. The new study offers the first evidence of how the vaccine will also work in school-age adolescents.

In the trial of 2,260 adolescents aged 12 to 15, there were 18 cases of coronavirus in the group that got a placebo dose and none in the group that got the vaccine, resulting in 100% efficacy in preventing COVID-19, the companies said in a statement.

The vaccine was well tolerated, with side effects in line with those seen among those aged 16 to 25 in the adult trial. It did not list the side effects for the younger group, but the adult trial’s side effects generally were mild to moderate and included injection-site pain, fever, headaches and fatigue.

The companies also studied a subset of teens to measure the level of virus-neutralizing antibodies a month after the second shot and found it was comparable to study participants aged 16 to 25 in the pivotal trial in adults.

Bourla said the company planned to seek emergency authorization from the U.S. Food and Drug Administration “in the next weeks and to other regulators around the world, with the hope of starting to inoculate this age group before the start of the next school year.”

Last week, the companies gave the first vaccine shots in a series of trials testing the vaccine in younger children, that will eventually go to those as young as 6 months of age.

    Source:
  • Reuters